What is Dopamine? What does it do?

A DEEP EXPLORATION OF THE DOPAMINERGIC SYSTEMS AND ITS ENHANCEMENT

Does CBD oil work for chronic pain management?

Effects

CBD is one of more than 120 compounds called cannabinoids.

Many plants contain cannabinoids, but people most commonly link them to cannabis.

Unlike other cannabinoids — such as tetrahydrocannabinol (THC) — CBD does not produce a euphoric “high” or psychoactive effect. This is because CBD does not affect the same receptors as THC.

The human body has an endocannabinoid system (ECS) that receives and translates signals from cannabinoids. It produces some cannabinoids of its own, which are called endocannabinoids. The ECS helps to regulate functions such as sleep, immune-system responses, and pain.

Does CBD make you high?

CBD is an entirely different compound from THC, and its effects are very complex. It is not psychoactive, meaning it does not produce a “high” or change a person’s state of mind, but it influences the body to use its own endocannabinoids more effectively.

According to one study posted to Neurotherapeutics, this is because CBD itself does very little to the ECS. Instead, it activates or inhibits other compounds in the endocannabinoid system.

For example, CBD stops the body from absorbing anandamide, a compound associated with regulating pain. So, increased levels of anandamide in the bloodstream may reduce the amount of pain a person feels.

Cannabidiol may also limit inflammation in the brain and nervous system, which may benefit people experiencing pain, insomnia, and certain immune-system responses.

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Kenneth Diaz

Chronic pain

The same report studied CBD use for general chronic pain. Researchers compiled the results of multiple systematic reviews covering dozens of trials and studies. Their research concluded that there is substantial evidence that cannabis is an effective treatment for chronic pain in adults.

A separate study in the Journal of Experimental Medicine supports these results. This research suggests that using CBD can reduce pain and inflammation.

The researchers also found that subjects were not likely to build up a tolerance to the effects of CBD, so they would not need to increase their dose continually.

They noted that cannabinoids, such as CBD, could offer helpful new treatments for people with chronic pain.

Multiple sclerosis

Multiple sclerosis (MS) is an autoimmune disease that affects the entire body through the nerves and brain.

Muscle spasms are one of the most common symptoms of MS. These spasms can be so great they cause constant pain in some people.

One report found that short-term use of CBD oil could reduce the levels of spasticity a person feels. The results are modest, but many people reported a reduction in symptoms. More studies on humans are needed to verify these results.

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Lorem ipsum dolor sit amet, consectetur adipisicing elit, sed do eiusmod tempor incididunt ut labore et dolore!
Kenneth Diaz

Other uses

CBD currently has a range of applications and promising possibilities.

These include:

Although more research is required to confirm some uses of CBD oil, it is shaping up as a potentially promising and versatile treatment.

In June 2018, the U.S. Food and Drug Administration (FDA) approved one form of CBD as a treatment for people with two rare and specific kinds of epilepsy, namely Lennox-Gastaut syndrome (LGS) or Dravet syndrome (DS).

The brand name of this drug is Epidiolex.

More generally, marijuana derived CBD products are not yet legal at the federal level but are legal under the laws of some states. Hemp derived CBD products that contain less than 0.3% THC are legal federally but are still illegal in certain states.

Dosage

The FDA does not regulate CBD for most conditions. As a result, dosages are currently open to interpretation, and people should treat them with caution.

Anyone who wishes to use CBD should first speak to a doctor about whether it is a good idea, and how much to take.

The FDA recently approved a purified form of CBD for some types of epilepsy, with the brand name Epidiolex. If you are using this medication, be sure to follow the doctor’s advice about doses.

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